MergeAlign: improving multiple sequence alignment performance by dynamic reconstruction of consensus multiple sequence alignments
نویسندگان
چکیده
منابع مشابه
Optimal Alignment of Multiple Sequence Alignments
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 12 CHAPTER 1: INTRODUCTION . . . . . . . . . . . . . . . . . . . . . . . . . 14 1.1 Perspective . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 14 1.2 Contributions . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 16 1.3 Overview . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ...
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MOTIVATION We introduce a novel approach to multiple alignment that is based on an algorithm for rapidly checking whether single matches are consistent with a partial multiple alignment. This leads to a sequence annealing algorithm, which is an incremental method for building multiple sequence alignments one match at a time. Our approach improves significantly on the standard progressive alignm...
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Multiple alignments of biological nucleic acid sequences are one of the most commonly used techniques in sequence analysis. These techniques demand a big computational load. We present a Genetic Algorithms (GA) that optimizes an objective function that is a measure of alignment quality (distance). Each individual in the population represents (in an efficient way) some underlying operations on t...
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ژورنال
عنوان ژورنال: BMC Bioinformatics
سال: 2012
ISSN: 1471-2105
DOI: 10.1186/1471-2105-13-117